WebA diverse set of phage lineages is associated with the bacterial plant-pathogen genomes sequenced to date. Analysis of 37 genomes revealed 5,169 potential genes (approximately 4.3 Mbp) of phage origin, and at least 50% had no function assigned or are nonessential to phage biology. Some phytopathogens have transcriptionally active prophage genes … WebHere a vaccination strategy that focuses antibody responses to conserved epitopes of the H3 hemagglutinin is described. The approach is based on antigenic silencing of the immunodominant major antigenic sites of an H3 protein from 2014 by replacing them with corresponding sequences of exotic avian hemagglutinins, yielding "mosaic" …

Publication Year: 2003 / Subject: bioassays - NALDC Search Results

WebApr 8, 2024 · These novel constructs, termed mosaic hemagglutinins, should provide enhanced protection and should be tested in clinical trials to assess their improved … WebInfluenza B viruses cause seasonal epidemics and are a considerable burden to public health. However, protection by current seasonal vaccines is suboptimal due to the antigenic changes of the circulating strains. In this study, we report a novel universal influenza B virus vaccination strategy based on mosaic hemagglutinins. We generated mosaic B … melbourne spine and brain centre

Hemagglutinin - Proteopedia, life in 3D

WebHemagglutinins (HA) are one of the two antigenic Glycoproteins inserted into the influenza virus' membrane. There are at least 16 different forms of HA antigens classified from H1 to H16. H1, H2, H3 are specific to human influenza. HAs have two main functions crucial for the viral infection cycle: 1. On the target cell, HA binds the receptor on ... WebNational Center for Biotechnology Information WebMosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses Nat Immunol. 2024 Mar;20 ... Immunization with the mosaic RBD-np elicited … melbourne south east australia post