WebApr 14, 2024 · MGORS is caused by disruption to DNA replication and is typically associated with early DNA replication processes [3,4,5,6,7,8,9,10,11,12].DNA replication is a complex multi-protein process that ... Webof targeted therapy, genetic landscape of hepatocarcinogenesis is necessary to be understood in detail. Here, we summarize the landscape of the liver cancer genome and its intratumor heterogeneity. Recent insight on early genetic alterations in hepatocarcinogenesis, especially those in early HCC and noncancerous liver tissues …
Genomic landscape of Chinese patients with ... - ScienceDirect
WebAs the complex genetic landscape of HCC would compromise the antitumor efficacy of targeted therapy, a deeper understanding of the genetic landscape of hepatocarcinogenesis is necessary. Recent comprehe nsive genetic analyses have revealed the driver genes of HCC, which accumulate during the multista ge process of … WebSci-Hub Genomic landscape of hepatocarcinogenesis. Journal of Human Genetics, 66 (9), 845–851 10.1038/s10038-021-00928-8. sci. hub. to open science. ↓ save. Shibata, … allmore cottage gratton
Genetic Landscape of Multistep Hepatocarcinogenesis. - Abstract ...
WebMay 1, 2024 · Hepatocellular carcinoma (HCC) is a global health issue and the fourth leading cause of cancer deaths worldwide. Large-scale HCC genome sequencing … WebGenomic landscape of hepatocarcinogenesis. Hepatocellular carcinoma (HCC) is a global health issue and the fourth leading cause of cancer deaths worldwide. Large-scale … WebMay 26, 2024 · Conclusions: This study revealed a unique genomic landscape of HBV-related HCC. Besides TP53 being the highest mutated gene, a significant fraction of patients was identified with TERT promoter mutations, suggesting that TERT may play a role in HBV-related hepatocarcinogenesis as a novel molecular marker. Furthermore, the most … all month calendar