Chromopyrrolic acid
WebAug 18, 2007 · The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one rebeccamycin biosynthetic enzyme is capable of generating low levels of the eight-electron oxidation product on its own, a second protein, RebC, is required to accelerate product … WebStaP on its own converts chromopyrrolic acid into three aglycone products, K252c, arcyriaflavin A, and 7-hydroxy-K252c; in the presence of StaC, K252c is the predominant …
Chromopyrrolic acid
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Webtion of tryptophan to the imine form of indole-3-pyruvic acid (IPA imine), and StaD then catalyzes the coupling of two molecules of IPA imine to yield chromopyrrolic acid (CPA). Finally, the key skeleton structure referred to as the indolocar-bazole core is constructed through the following two oxidation steps by StaP and StaC (2, 4) (Fig. 1B). WebApr 1, 2009 · The ‘open’ chromopyrrolic acid intermediate must be now converted into a ‘closed’ indolocarbazole aglycone either containing an imide (rebeccamycin-like as in arcyriaflavin A) or an amide (staurosporine-like as in K252c) function at the pyrrole moiety.
Web暨南大学,数字图书馆. 开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 Web3- (3-Indolyl)-2-oxopropanoic acid, 3-Indolylpyruvic acid. Empirical Formula (Hill Notation): C11H9NO3. CAS Number: 392-12-1. Molecular Weight: 203.19. Beilstein: 172966.
WebFeb 6, 2013 · Howard-Jones, A.R.; Walsh, C.T. Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD. Biochemistry 2005, 44, 15652–15663. [Google Scholar] Onaka, H. Biosynthesis of indolocarbazole and goadsporin, two different heterocyclic antibiotics produced by … WebNIOSH. At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration: (APF = 10,000) Any self-contained breathing apparatus that …
WebSep 25, 2007 · The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one rebeccamycin biosynthetic enzyme is capable of generating low levels of the eight-electron oxidation product on its own, a second protein, RebC, is required to accelerate product …
WebIndole-3-pyruvic acid can be used: As a precursor for the synthesis of chromopyrrolic acid by a heme-containing enzyme.As a reactant in the Biginelli-like scaffold syntheses. Packaging. 1, 5 g in poly bottle. Linkage. α-Keto analogue … grand mall offerWebMay 1, 2015 · We provide the first experimental evidence for intermediates being involved in catalysis by RebD in generating the chromopyrrolic acid (CPA) scaffold of … chinese food near me 77536WebTwo complementary concise total syntheses of lycogarubin C ( 1) and lycogalic acid ( 2, aka chromopyrrolic acid) are detailed utilizing a 1,2,4,5-tetrazine → 1,2-diazine → pyrrole Diels−Alder strategy and enlisting acetylenic dienophiles. Supporting Information Full experimental details and compound characterizations. grandma lives on cruise shipWebJul 10, 2007 · Staurosporine isolated from Streptomyces sp. TP-A0274 is a member of the family of indolocarbazole alkaloids that exhibit strong antitumor activity. A key step in … chinese food near me 78223WebJun 29, 2024 · 从链霉菌分离出的咔唑生物碱星孢菌素 (Staurosporine)具有强抗癌作用, 其生物合成的关键步 骤是由 P450 StaP 催化底物色素吡咯酸(chromopyrrolic acid, CPA)氧化脱氢, 形成分子内 C—C 键成咔唑环, 经 氧化脱羧完成. grandma literacy isWebAug 5, 2024 · Indolocarbazoles are biosynthesized through the successive modification of chromopyrrolic acid, a dimer of tryptophan. Furthermore, they are closely related to other groups of tryptophan derived natural products, most significantly the indolotryptolines. chinese food near me 79901WebApr 5, 2012 · The indolocarbazole biosynthetic enzymes StaC, InkE, RebC, and AtmC mediate the degree of oxidation of chromopyrrolic acid on route to the natural products staurosporine, K252a, rebeccamycin, and AT2433-A1, respectively. grand mall industrial area